产品货号：
GS4518
中文名称：
重组人MIP-1β/CCL4
英文名称：
Recombinant Human Macrophage Inflammatory Protein-1 beta/CCL4
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 7.8kDa,a single non-glycosylated polypeptide chain containing 69 amino acids.
储存条件：冷冻（-20℃）
概述
CCL4 encoded by the CCL4 gene,also known as Macrophage Inflammatory Protein-1β(MIP-1β)is a CC chemokine with specificity for CCR5 receptors and it is a major HIV-suppressive factor produced by CD8+ T cells.It is a monokine with inflammatory and chemokinetic properties.Recombinant CCL4 induces a dose-dependent inhibition of different strains of HIV-1,HIV-2,and simian immunodeficiency virus(SIV).Specifically,MIP-1-beta(3-69)is also a ligand for CCR1 and CCR2 isoform B.Recombinant human CCL4 contains 69 amino acids and it shares 77%and 80%a.a.sequence identity with murine and rat CCL4,respectively.Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人MIP-1β/CCL4，MIP-1β/CCL4, Human
储存条件：冷冻（-20℃）
概述
CCL4 encoded by the CCL4 gene,also known as Macrophage Inflammatory Protein-1β(MIP-1β)is a CC chemokine with specificity for CCR5 receptors and it is a major HIV-suppressive factor produced by CD8+ T cells.It is a monokine with inflammatory and chemokinetic properties.Recombinant CCL4 induces a dose-dependent inhibition of different strains of HIV-1,HIV-2,and simian immunodeficiency virus(SIV).Specifically,MIP-1-beta(3-69)is also a ligand for CCR1 and CCR2 isoform B.Recombinant human CCL4 contains 69 amino acids and it shares 77%and 80%a.a.sequence identity with murine and rat CCL4,respectively.Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞96%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 5.0-20ng/ml. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 20mMPB,pH 7.4,150 mM NaCl. |
| 内毒素 | Less than 1 EU/ug of rHuMIP-1β/CCL4 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN |
相关搜索：重组人MIP-1β/CCL4，MIP-1β/CCL4, Human